Trisomy 18 - Edward's Syndrome

What is Trisomy 18?

Trisomy 18 or Edward's Syndrome is a relatively common syndrome caused by the presence of an extra number 18 chromosome, which leads to multiple abnormalities including severe mental retardation, digestive problems, heart failure, renal failure, respiratory failure, blindness, deafness and extreme physical limitations.

Infants often have a low birth weight, a small, abnormally shaped head; a small jaw and mouth, clenched fists with overlapping fingers, severe heart defects, and renal abnormalities. Approximately 95% of fetus' with trisomy 18 are miscarried or stillborn. Most children born with this defect die within their first month. The high mortality rate is usually due to the presence of cardiac, renal malformations, and feeding problems.

For more information on this disorder please visit:

eMedicine WebMD

Genetic Home Referrence U.S. National Library of Medicine

Trisomy 18 Org. Trisomy 18 Foundation

MedlinePlus A service of the U.S. National Library of Medicine from the National Institutes of Health


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